منابع مشابه
H2A.Z-Mediated Genome-Wide Chromatin Specialization.
The characterization of the involvement of different histone post-translational modifications (PTMs) and histone variants in chromatin structure has represented one of the most recurrent topics in molecular biology during the last decade (since 1996). The interest in this topic underscores the critical roles played by chromatin in such important processes as DNA packaging, DNA repair and recomb...
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Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure. The availability of genome-wide maps of nucleosome positions has led to an explosion of information about how nucleosomes are assembled at tran...
متن کاملHigh-Resolution Genome-wide Mapping of the Primary Structure of Chromatin
The genomic organization of chromatin is increasingly recognized as a key regulator of cell behavior, but deciphering its regulation mechanisms requires detailed knowledge of chromatin's primary structure-the assembly of nucleosomes throughout the genome. This Primer explains the principles for mapping and analyzing the primary organization of chromatin on a genomic scale. After introducing chr...
متن کاملMPE-seq, a new method for the genome-wide analysis of chromatin structure.
The analysis of chromatin structure is essential for the understanding of transcriptional regulation in eukaryotes. Here we describe methidiumpropyl-EDTA sequencing (MPE-seq), a method for the genome-wide characterization of chromatin that involves the digestion of nuclei withMPE-Fe(II) followed by massively parallel sequencing. Like micrococcal nuclease (MNase), MPE-Fe(II) preferentially cleav...
متن کاملGenome-Wide Mapping of Chromatin State of Mouse Forelimbs.
BACKGROUND Cell types are defined at the molecular level during embryogenesis by a process called pattern formation and created by the selective utilization of combinations of sequence specific transcription factors. Developmental programs define the sets of genes that are available to each particular cell type, and real-time biochemical signaling interactions define the extent to which these s...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2009
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.78.071107.134639